On the 3rd July 1693, the Governor of the Cape, Simon van der Stel, granted the land to Henning Hüsing, who named the farm Meerlust, describing the sense of pleasure he obtained from the sea breezes that blew inland from False Bay.
Johannes Albertus Myburgh bought Meerlust in January 1757. His ownership marked the foundation of the Myburgh Dynasty.

The work depicted, by Johann Frederici, gives a lively impression of life on the farm at the end of the 18th Century.
Hannes Myburgh, eighth generation owner of Meerlust, graduated from the University of Stellenbosch with a Bachelor of Arts degree majoring in French and English in 1982, before studying winemaking at Geisenheim in Germany. Hannes worked at Chateau Lafite in France and Von Oetinger in Germany.

Winemaking at Meerlust follows time-honoured tradition as well as modern techniques. The approach remains non-interventionist in order to allow each vineyard to express its individuality.

The iconic Meerlust Rubicon is one of the most famous wines of South Africa.